Helmholtz Imaging Projects


Helmholtz Imaging Projects aim to initiate cross-cutting research collaborations and identify innovative research topics in the field of imaging and data science.

Funds for Helmholtz Imaging Projects are annually granted to cross-disciplinary research teams for collaborative mid-term projects.

Ideally, Helmholtz Imaging Projects are co-created with users and non-academic stakeholders to ensure the quick adoption of results.

Funding for the first Helmholtz Imaging projects started in December 2020. Many teams have since begun work on major challenges and pressing issues facing society to develop sustainable solutions for tomorrow and beyond.

Discover these outstanding and fascinating research projects with us or become a part of Helmholtz Imaging Projects and apply for your own project. The next call for Helmholtz Imaging Projects is OPEN until July 30, 2025. Find out more about the project call in this summary.

Helmholtz Imaging Projects – ongoing


 

HIT Permafrost

The Hidden Image of Thawing Permafrost

The project aims to develop a method for determining just how extensively thaw processes have already progressed in permafrost regions. The machine learning approach to be developed will be used to analyse radar images from aircraft in order to learn more about the properties of the subsurface permafrost.

Hyperspectral data cube symbolizing the general remote sensing and hyperspectral imagery domains, showing an aerial view of a landscape at the front with bluish, green and reddish colored lines leading to the back of the cube.
Image: Aaron Christian Banze | info

HYPER-AMPLIFAI

Advancing Visual Foundation Models for Multi-/Hyperspectral Image Analysis in Agriculture/Forestry

The project aims to make advanced AI models accessible for Hyperspectral Earth Observation, reducing computational demands, and improving environmental assessments through user-friendly interfaces.

Decorative image, HI ImageTox
Image: Jonas Baumann, HIPS | info

ImageTox

Automated image-based Detection of Early Toxicity Events in Zebrafish Larvae

ImageTox wants to establish an automated image-based system to assess zebrafish larval development. This will allow for a fast and unbiased evaluation of pathophysiological events during toxicological studies. To achieve this, the imaging process has to be optimized and a reliable model for sequence recognition based on deep learning has to be developed.

This image shows simulation results comparing MWF mapping with single inversions of "T2-decay" data, "T2*-decay" data, and with joint inversion of both. The joint inversion is significantly closer to ground truth, as the second row shows.
info

JIMM2

3D Myelin Mapping with AI and Uncertainty Quantification

Changes in brain myelin are linked to many neurological diseases. This project aims to improve myelin water imaging, enabling more accurate and accessible diagnostics.

Project overview image, summarizing the MemBrain-structure workflow from membrane segmentation and particle picking to subtomogram averaging.
Image: MemBrain-structure | info

MemBrain-structure

AI-driven End-to-End Pipeline for Membrane Protein Structure Determination by Cryo-ET

An open-source AI pipeline automates cryo-ET data analysis, turning raw tilt-series into 3D membrane protein structures relevant for biology and medicine.

Drone-based radar imaging and AI reconstruct 3D soil moisture underground, enabling improved monitoring of water resources and environmental processes.
Image: Moisture3D | info

Moisture3D

Mapping of Integral Soil Tomography Using Radar Enhancement in 3D

Drone-based radar imaging and AI reconstruct 3D soil moisture underground, enabling improved monitoring of water resources and environmental processes.

Comparison figure with three side-by-side grayscale image panels labeled “Conventional recon,” “Dual Recon Tracer 1,” and “Dual Recon Tracer 2.” Each panel contains circular shapes of varying size and intensity, illustrating differences in how the structures appear under the three reconstruction methods.
Image: HI Project MULTI-TRACE | info

MULTI-TRACE

Simultaneous quantitative multi-molecular PET imaging of two radiopharmaceuticals: from algorithmic developments to applications in neuroscience and oncology

New open-source algorithms enable dual-tracer PET imaging, allowing two molecular processes to be studied simultaneously in a single scan.

Visual for Helmholtz Imaging Project PlastoView
Image: PlastoView | info

PlastoView

Microplastic Detection with the PlastiScope

Water quality is essential for ecosystems and human health, yet it’s increasingly threatened by microplastics. This project develops image-based methods for detecting both plankton and microplastics using a new low-cost, mobile system.

Visual, Helmholtz Imaging Project POINTR, topic: Mapping Boreal Forest Change Using 3D Radar and Point Cloud Data
Image: Stefan Kruse | info

POINTR

Mapping Boreal Forest Change Using 3D Radar and Point Cloud Data

Global warming is reshaping northern boreal forests. This project maps forest structure and ecosystem services using high-resolution radar satellite monitoring combined with 3D imaging data.

 

SyNaToSe

Leveraging Cross-Domain Synergies for Efficient Machine Learning of Nanoscale Tomogram Segmentation

The aim is to develop an adaptable algorithm that can be used to perform different tasks in data and image analysis without needing to be trained with new, laboriously annotated images for each separate task.

Image: DLR

TerraByte-DNN2Sim

On the trail of the mystery of the laws of calving

Researchers still face a mystery when it comes to the laws by which glaciers calve. This project aims to use satellite imagery, artificial intelligence, mathematical optimisation and a new data processing pipeline to track the movements of glacier fronts in Antarctica to get closer to solving the mystery.

Decorative image explaining WeMonitor
Image: WeMonitor | info

WeMonitor

Satellite-based Earth observation to detect natural hazards

Satellite imagery makes it possible to detect spatio-temporal anomalies on the Earth’s surface, including natural hazards such as landslides, deforestation, or the emergence of large waste dump sites. This project aims to use artificial intelligence to detect these changes at an early stage and to be able to monitor their progress.

Image of HI Project "X-BRAIN"
Image: X-BRAIN | info

X-BRAIN

Cross-modality representation learning for brain analysis and data integration

This project aims to develop AI methods that support the integration of multimodal imaging data into human brain atlases, thereby advancing the analysis of brain structure in both health and disease.