The Human Radiome Project is a collaborative effort involving partners from Helmholtz Centers, industry, academia and medical facilities. It aims to consolidate a vast array of 3D radiological images, such as MRIs and CT scans, into a foundational AI model, striving to deepen our understanding of human anatomy and pathologies. By representing the full spectrum of radiologic information, the “Human Radiome” is set to enhance personalized medicine, seamlessly integrating structural, functional, and pathological information.