MULTI-TRACE

Simultaneous quantitative multi-molecular PET imaging of two radiopharmaceuticals: from algorithmic developments to applications in neuroscience and oncology

Comparison figure with three side-by-side grayscale image panels labeled “Conventional recon,” “Dual Recon Tracer 1,” and “Dual Recon Tracer 2.” Each panel contains circular shapes of varying size and intensity, illustrating differences in how the structures appear under the three reconstruction methods.

Image: HI Project MULTI-TRACE | info

Positron emission tomography (PET) is a widely used imaging technique in neuroscience, oncology and pharmaceutical research, enabling the quantification of molecular processes using specific radiotracers. Currently, PET investigations are typically limited to a single tracer per scan, restricting insights to one molecular process at a time.

MULTI-TRACE aims to overcome this limitation by developing novel algorithms that enable the simultaneous detection and quantification of two different radiotracers within a single PET scan. The software will be compatible with both research and clinical PET systems and a range of radiopharmaceuticals, including tracers whose production will be established within the project. Released as a user-friendly open-source tool, the approach is expected to significantly advance PET imaging in research and clinical practice.

Project partners

HZDR, FZJ:

Prof Dr Anja Braune
Dr Elisabeth Pfaehler

Duration

36 months

Primary Contact

Prof. Dr. Anja Braune

a.braune@hzdr.de

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